Fig. 2.

Heritability enrichment of the top 12 genomic functional elements. We partitioned the SNP-heritability of serum 25-hydroxyvitamin D concentrations into 24 publicly available genomic functional elements using LD-score regression. We plotted the enrichment (Y axis) for each of the 12 top annotations (as shown in X axis) into a bar chart. Gray bars and blue bars represent the annotations with and without the 500 base-pair windows. The height of each bar represents magnitude of enrichment. Significant estimates of enrichment that passed Bonferroni corrections (P-value for enrichment <0.05/24) are marked with double stars. TSS transcription start sites, DHS DNase I hypersensitive sites, TFBS transcription factor binding sites, Repressed repressed regions