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. Author manuscript; available in PMC: 2018 Jan 18.
Published in final edited form as: Biochem J. 2017 Jun 6;474(12):2039–2049. doi: 10.1042/BCJ20170200

Figure 3. Negatively charged lipids on t-SNARE side are essential for the positive role of A-syn in vesicle docking.

Figure 3

Histograms of docking probabilities without (−A-syn) or with 2.5 μM A-syn (+A-syn) using t-vesicles containing 20 mol% DOPS and v-vesicles without DOPS (t20/v0) (A), both t- and v-vesicles without DOPS (t0/v0) (B), t-vesicles without DOPS and v-vesicles containing 20 mol% DOPS (t0/v20) (C), and both t- and v-vesicles containing 20 mol% DOPS (t20/v20) (D). Error bars denote the SD of three independent experiments, and movies recorded from more than five randomly selected screens were analyzed and averaged in each experiment.