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. 2018 Jan 17;8:964. doi: 10.1038/s41598-018-19301-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BDNF is upregulated in P2RX4 neurons 24 h after peripheral inflammation. BDNF expression was analyzed in BDNF-HA mice in which a HA epitope is added at the carboxyl terminus of BDNF. (A) In DRG sections of BDNF^HA/HA mice, HA-immunofluorescence was detected in control conditions (left panel) and the number of labeled neurons increases 24 h after CFA injection (right panel). Scale bar 100 µm. (B) Co-immunostaining of βgal and BDNF in control and 24 h after CFA injection in DRG sections. βgal is expressed in a subset of BDNF-positive neurons. Scale bar 50 µm. (C) Representative pictures of Isolectin B4 (IB4) and HA staining in the spinal cord in control and CFA-conditions. Note the increase of BDNF staining in lamina I in CFA conditions and the absence of co-localization of the two markers. Scale bar 50 µm.