Table 4.
Meta-analysis of differences of Lumbar, Femoral Neck and Ward’s triangle BMD between each genotype of VDR ApaI, BsmI, TaqI, Cdx2 and FokI polymorphism.
| VDR ApaI | Aa vs. AA | aa vs. AA | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Test of differences | Model | Test of heterogeneity | Test of differences | Model | Test of heterogeneity | |||||||
| N | WMD (95% CI) | P value | P value | I2 (%) | N | WMD (95% CI) | P value | P value | I2 (%) | |||
| Lumbar BMD (Caucasian) | 6 | −0.00 (−0.04, 0.04) | 0.896 | R | <0.001 | 90.5 | 5 | 0.01 (−0.04, 0.07) | 0.571 | R | <0.001 | 87.1 |
| Femoral Neck BMD (Caucasian) | 5 | 0.02 (−0.03, 0.07) | 0.488 | R | <0.001 | 96.5 | 4 | 0.06 (0.05, 0.08) | <0.001 | F | 0.156 | 42.5 |
| VDR BsmI | Bb vs. bb | BB vs. bb | ||||||||||
| Lumbar BMD | ||||||||||||
| Overall | 18 | 0.00 (−0.01, 0.02) | 0.699 | R | <0.001 | 82.9 | 18 | 0.01 (−0.01, 0.02) | 0.467 | R | <0.001 | 78 |
| Caucasian | 16 | −0.00 (−0.02, 0.01) | 0.684 | R | <0.001 | 78.5 | 16 | −0.00 (−0.02, 0.02) | 0.988 | R | <0.001 | 76 |
| Asian | 2 | 0.05 (−0.05, 0.14) | 0.344 | R | <0.001 | 94.4 | 2 | 0.07 (−0.01, 0.14) | 0.078 | R | 0.068 | 70 |
| Femoral Neck BMD | ||||||||||||
| Overall | 14 | 0.01 (−0.00, 0.03) | 0.061 | R | <0.001 | 70.2 | 15 | 0.01 (−0.02, 0.03) | 0.618 | R | <0.001 | 89.5 |
| Caucasian | 12 | 0.01 (−0.00, 0.03) | 0.087 | R | <0.001 | 73.9 | 13 | 0.01 (−0.02, 0.04) | 0.484 | R | <0.001 | 90.1 |
| Asian | 2 | 0.01 (−0.01, 0.03) | 0.43 | R | 0.456 | 0 | 2 | −0.02 (−0.05, 0.02) | 0.302 | R | 0.14 | 54 |
| Ward’s triangle BMD | ||||||||||||
| Overall | 3 | −0.01 (−0.04, 0.03) | 0.645 | R | 0.095 | 57.6 | 3 | 0.02 (−0.07, 0.10) | 0.675 | R | 0.002 | 83.7 |
| Asian | 2 | 0.01 (−0.02, 0.03) | 0.55 | R | 0.444 | 0 | 2 | 0.05 (−0.02, 0.13) | 0.156 | R | 0.051 | −73.7 |
| VDR TaqI | Tt vs. TT | tt vs. TT | ||||||||||
| Lumbar BMD (Caucasian) | 6 | −0.12 (−0.26, 0.03) | 0.108 | R | <0.001 | 99.4 | 6 | −0.15 (−0.30, 0.01) | 0.06 | R | <0.001 | 98.3 |
| Femoral Neck BMD (Caucasian) | 4 | −0.02 (−0.06, 0.01) | 0.186 | R | <0.001 | 93.7 | 4 | −0.05 (−0.10, 0.00) | 0.072 | R | <0.001 | 94.4 |
| VDR Cdx2 | GA vs. GG | AA vs. GG | ||||||||||
| Lumbar BMD | ||||||||||||
| Overall | 4 | −0.15 (−0.25, −0.04) | 0.007 | R | <0.001 | 98.9 | 3 | −0.11 (−0.26, 0.05) | 0.176 | R | <0.001 | 97.2 |
| Caucasian | 3 | −0.22 (−0.43, −0.01) | 0.037 | R | <0.001 | 99.2 | 2 | −0.19 (−0.54, 0.15) | 0.274 | R | <0.001 | 97.5 |
| Femoral Neck BMD | ||||||||||||
| Overall | 3 | 0.02 (−0.01, 0.04) | 0.229 | R | 0.002 | 84.2 | 2 | 0.01 (−0.08, 0.11) | 0.776 | R | 0.01 | 84.9 |
| Caucasian | 2 | 0.02 (−0.02, 0.07) | 0.254 | R | 0.011 | 84.5 | ||||||
| VDR FokI | Ff vs. FF | ff vs. FF | ||||||||||
| Lumbar BMD | ||||||||||||
| Overall | 6 | −0.01 (−0.03, 0.01) | 0.342 | R | 0.003 | 71.9 | 6 | −0.02 (−0.07, 0.03) | 0.481 | R | <0.001 | 84.9 |
| Caucasian | 5 | −0.01 (−0.04, 0.02) | 0.444 | R | 0.001 | 77.2 | 5 | −0.02 (−0.08, 0.04) | 0.584 | R | <0.001 | 87.9 |
| Femoral Neck BMD (Caucasian) | 4 | −0.02 (−0.02, −0.01) | <0.001 | F | 0.626 | 0 | 4 | −0.02 (−0.05, 0.01) | 0.149 | R | 0.016 | 71.1 |
R: random effect model.
F: fixed effect model.