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. 2018 Jan 17;60:3. doi: 10.1186/s13028-018-0357-9

Table 1.

Validation parameters of six anticoagulant rodenticides

Compound Calibration range (ng/mL or ng/g) Blood Faeces QC-sample conc. Blood Faeces
Mean R2 RSD (%) Mean R2 RSD (%) Within-day precision RSD (%) Between-day precision RSD (%) Bias (%) ME% RE% Within-day precision RSD (%) Between-day precision RSD (%) Bias (%) ME% RE%
Coumatetralyl 1.5–731 (0.0050–2.5 µM) 0.999 0.061 0.998 0.24 2.3
88
585		 4.0
3.6
6.0		 7.9
8.7
11		 − 3.5
5.2
− 1.8		 90
93		 10
15		 2.8
5.7
6.5		 15
13
15		 − 3.6
1.6
8.4		 109
96		 69
Bromadiolone 2.6–1319 (0.0050–2.5 µM) 0.998 0.21 0.998 1 4.2
158
1055		 5.8
5.7
7.5		 17
14
17		 16
13
− 4.1		 100
97		 44
52		 15
17
16		 16
18
13		 − 7.7
− 3.1
− 11		 63
56		 32
Difenacoum 2.2–1111 (0.0050–2.5 µM) 0.997 0.33 0.999 0.10 3.6
133
889		 9.1
2.2
8.9		 13
15
15		 5.5
7.8
6.1		 101
97		 43
87		 13
14
15		 18
17
15		 − 5.3
− 6.1
− 11		 62
60		 26
Flocoumafen 2.7–1356 (0.0050–2.5 µM) 0.997 0.41 0.995 1.1 4.3
163
1085		 8.0
3.0
6.4		 14
14
15		 2.7
6.6
− 4.6		 95
92		 80
90		 11
9.0
6.3		 19
17
19		 − 5.5
− 2.8
− 14		 45
32		 18
Brodifacoum 2.6–1309 (0.0050–2.5 µM) 0.998 0.37 0.999 0.11 4.2
157
1047		 8.6
3.1
9.1		 15
14
11		 8.4
6.2
− 3.1		 93
90		 61
78		 9.2
9.3
6.4		 19
18
19		 − 1.7
− 2.1
− 18		 32
32		 25
Difethialone 2.7–1349 (0.0050–2.5 µM) 0.997 0.37 0.998 0.17 4.3
164
1079		 8.9
6.4
13		 14
12
17		 16
12
3.1		 86
81		 69
84		 10
11
5.1		 17
11
16		 1.3
0.8
− 9.4		 31
27		 22