Table 2.

Multivariate Cox’s proportional hazards regression model each evidence-based medications

		< 60 years old			60–75 years old			≥75 years old
Medicines	Mortality	Unadjusted HR (95% CI)	Adjusted HR (98% CI)	Propensity score analysis unadjusted HR (98% CI)	Unadjusted HR (96% CI)	Adjusted HR (99% CI)	Propensity score analysis unadjusted HR (98% CI)	Unadjusted HR (97% CI)	Adjusted HR (100% CI)	Propensity score analysis unadjusted HR (98% CI)
Aspirin	All-cause death	0.13 (0.06–0.27)	0.12 (0.05–0.25)	0.19 (0.04–0.86)	0.16 (0.11–0.22)	0.17 (0.11–0.24)	0.17 (0.08–0.36)	0.21 (0.13–0.32)	0.22 (0.14–0.34)	0.21 (0.09–0.45)
	CV death	0.07 (0.03–0.15)	0.06 (0.02–0.15)	0.09 (0.01–0.74)	0.11 (0.07–0.18)	0.12 (0.07–0.19)	0.16 (0.06–0.41)	0.17 (0.09–0.30)	0.17 (0.09–0.31)	0.26 (0.10–0.66)
Clopidogrel	All-cause death	0.16 (0.08–0.32)	0.14 (0.07–0.28)	0.26 (0.07–0.94)	0.25 (0.18–0.36)	0.26 (0.18–0.38)	0.20 (0.10–0.40)	0.30 (0.19–0.47)	0.30 (0.19–0.47)	0.42 (0.23–0.77)
	CV death	0.11 (0.05–0.27)	0.11 (0.05–0.27)	0.11 (0.01–0.85)	0.14 (0.09–0.22)	0.15 (0.09–0.23)	0.14 (0.05–0.36)	0.27 (0.15–0.48)	0.26 (0.14–0.48)	0.42 (0.19–0.95)
Dual-antiplatelet	All-cause death	0.18 (0.09–0.36)	0.15 (0.07–0.30)	0.06 (0.01–0.47)	0.26 (0.18–0.37)	0.27 (0.19–0.38)	0.18 (0.09–0.36)	0.33 (0.21–0.51)	0.34 (0.22–0.53)	0.38 (0.20–0.69)
	CV death	0.12 (0.05–0.29)	0.12 (0.05–0.28)	0.01 (0–1.53)	0.17 (0.11–0.27)	0.17 (0.11–0.28)	0.16 (0.07–0.38)	0.31 (0.17–0.55)	0.31 (0.17–0.56)	0.42 (0.19–0.92)
Statins	All-cause death	0.18 (0.08–0.38)	0.16 (0.08–0.35)	0.43 (0.15–1.24)	0.29 (0.20–0.41)	0.30 (0.21–0.43)	0.08 (0.03–0.23)	0.20 (0.13–0.31)	0.20 (0.12–0.31)	0.31 (0.15–0.61)
	CV death	0.10 (0.04–0.25)	0.10 (0.04–0.24)	0.29 (0.08–1.05)	0.22 (0.14–0.35)	0.23 (0.14–0.37)	0.10 (0.03–0.32)	0.15 (0.09–0.28)	0.15 (0.08–0.27)	0.31 (0.13–0.75)
ACEIs or ARBs	All-cause death	0.86 (0.43–1.74)	0.89 (0.44–1.80)	0.83 (0.42–1.64)	0.48 (0.34–0.68)	0.50 (0.35–0.70)	0.43 (0.29–0.64)	0.48 (0.31–0.74)	0.54 (0.35–0.84)	0.44 (0.27–0.70)
	CV death	0.54 (0.22–1.35)	0.54 (0.22–1.34)	0.47 (0.19–1.14)	0.41 (0.25–0.65)	0.42 (0.26–0.68)	0.31 (0.17–0.55)	0.41 (0.23–0.73)	0.45 (0.25–0.83)	0.35 (0.18–0.69)
Beta-blockers	All-cause death	0.49 (0.25–0.97)	0.50 (0.25–1.00)	0.60 (0.27–1.32)	0.34 (0.24–0.47)	0.35 (0.25–0.48)	0.36 (0.24–0.55)	0.65 (0.43–0.99)	0.65 (0.42–1.00)	0.63 (0.40–0.99)
	CV death	0.33 (0.14–0.76)	0.35 (0.15–0.83)	0.37 (0.13–1.03)	0.31 (0.19–0.48)	0.32 (0.20–0.51)	0.27 (0.14–0.50)	0.44 (0.25–0.78)	0.44 (0.25–0.80)	0.34 (0.17–0.67)

Abbreviations: CAD Coronary artery disease, CI Confidence interval, CV Death: cardiovascular death, HR Hazard ratio, LDL-C Low-density lipoprotein-cholesterol, STEMI: ST-segment elevated myocardial infarction.Adjusted factor: sex, history of hypertension, history of diabetes mellitus, and history of heart failure, history of dyslipidemia, smoking status, eGFR and hepatic enzymes