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. 2017 Nov 17;15(1):1007–1013. doi: 10.3892/ol.2017.7440

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Copyright: © Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — WWTR1 is a target of miR-144. (A) WWTR1 was detected using western blot analysis in PTC, denoted by T, and adjacent non-cancerous tissues, denoted by N, from 15 (1–15) patients. WWTR1 was significantly overexpressed in PTC tissues compared with the adjacent non-cancerous tissue. (B) Ectopic overexpression of miR-144 resulted in the downregulation of WWTR1 in the PTC cell line IHH4. The protein expression of WWTR1 was significantly downregulated in the overexpressed miR-144 group compared with in the NC group. *P<0.05, **P<0.01. WWTR1, WW domain containing transcription regulator 1; PTC, papillary thyroid carcinoma; NC, negative control.