Table I.
Summary of the six SNPs in the four hypoxia-related genes in the present study.
| Gene | SNP IDa | Chromosomeb | Function | Allele | HW test P-value |
|---|---|---|---|---|---|
| MB | rs7292 | ch.22:35610998 | Synonymous | T>C | 0.912 |
| MB | rs7293 | ch.22:35611028 | Synonymous | G>A | 0.911 |
| ABCG2 | rs2231142 | ch.4:88131171 | Missense | C>A | 0.479 |
| MLH1 | rs1800734 | ch.3:36993455 | 5′UTR | G>A | 0.505 |
| MLH1 | rs9852810 | ch.3:37027478 | Intron variant | G>A | 1.000 |
| PARP-1 | rs1136410 | ch.1:226367601 | Missense | T>C | 0.878 |
a
According to the dbSNP database
b
The SNP location based on the NCBI Human Genome Build 37.5. SNP, single nucleotide polymorphism; HW, Hardy-Weinberg; MB, myoglobin; ABCG2, ATP binding cassette subfamily G member 2; MLH1, MutL homolog 1; PARP-1, Poly(ADP-ribose) polymerase 1; UTR, untranslated region.