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. 2017 Nov 9;15(1):1357–1361. doi: 10.3892/ol.2017.7388

Figure 2.

Figure 2.

Impact of IL-6 on the maintenance of CSC-like status. (A) Impact of IL-6 on CSC markers. The expression of CD44 increased in cells cultured in suspension when they were exposed to IL-6. In contrast, the expression of c-kit was decreased in cells cultured in suspension when they were exposed to IL-6. These results seemed paradoxical and are discussed in the Discussion section. (B) Impact of IL-6 on the mTOR pathway. The phosphorylation of S6, the indicator of mTOR pathway activation, increased in cells cultured in suspension when they were exposed to IL-6.