Table 5.
Comparison of acid base status between saline vs. balance fluid based on time (time-treatment interaction)
| Parameter | Type of fluid | 0 hours | 8 hours | 16 hours | 24 hours | P-value (F) |
|---|---|---|---|---|---|---|
| Mean (95%CI) | Mean (95%CI) | Mean (95%CI) | Mean (95%CI) | |||
| pH | Saline | 7.36 (7.35, 7.39) | 7.35 (7.32, 7.37) | 7.38 (7.36, 7.41) | 7.37 (7.36, 7.39) | 0.572 (0.67) |
| Balanced | 7.37 (7,35, 7.39) | 7.37 (7.34, 7.39) | 7.39 (7.37, 7.42) | 7.40 (7.38, 7.42) | ||
| pCO2 | Saline | 36.11 (34.07, 38.15) | 38.00 (35.99, 40.02) | 34.02 (32.34, 35.69) | 36.68 (35.26, 38.08) | 0.004 (4.89) |
| Balanced | 38.69 (36.59, 40.80) | 35.33 (33.25, 37.42) | 36.22 (34.49, 37.95) | 36.62 (35.16, 38.08) | ||
| BE− | Saline | −4.00 (−5.26, −2.76) | −3.85 (−4.96, −2.74) | −3.77 (−5.00, −2.53) | −3.20 (−4.26, −2.14) | 0.049 (2.78) |
| Balanced | −2.17 (−3.45, −0.88) | −4.15 (−5.30, −3.00) | −2.21 (−3.47, −0.95) | −1.35 (−2.43, −0.27) | ||
| HCO3− | Saline | 21.08 (20.06, 22.11) | 20.76 (19.62, 21.89) | 21.23 (20.21, 22.24) | 22.03 (21.24, 22.82) | 0.031 (4.65) |
| Balanced | 22.83 (21.76, 23.88) | 20.53 (19.35, 21.70) | 22.89 (21.85, 23.94) | 23.48 (22.66, 24.28) | ||
| lactate | Saline | 3.25 (1.49, 5.01) | 1.70 (1.44, 1.96) | 1.78 (1.12, 2.45) | 1.12 (0.99,1.26) | 0.571 (0.67) |
| Balanced | 2.80 (0.98, 4.61) | 1.94 (1.67, 2.20) | 1.49 (0.80, 2.18) | 1.27 (1.13, 1.41 |
Repeated measures ANOVA between group analysis with regard to time was applied. Assumption of normality, homogenicity of variance and compound symmetry were checked and were fulfilled.