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. 2017 Nov 10;15(1):864–872. doi: 10.3892/etm.2017.5482

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Copyright: © Xiao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Effect of SDHB and AMPK on aerobic glycolysis in CRC cells. SDHB was overexpressed or knocked down in HT-29 CRC cells. A total of 0.1 mM AICAR (an AMPK activator) and 20 µm/l Compound C (an AMPK inhibitor) were added to cells to activate and inhibit the activity of AMPK, respectively. Intracellular lactic acid levels were assessed using a lactic acid assay kit. *P<0.05 vs. the control group. SDHB, succinate dehydrogenase-B; AMPK, adenosine monophosphate activated protein kinase; CRC, colorectal cancer; AICAR, 5-aminoimidazole-4-carboxamide ribonucleotide; OV, SDHB expression vector; shR, shRNA targeting SDHB; Act, AMPK activator; Inh, AMPK inhibitor.