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. 2017 Nov 14;15(1):1021–1029. doi: 10.3892/ol.2017.7398

Figure 4.

Figure 4.

Effect of ginkgol C17:1 on the AMPK/ULK1 pathway. (A) Following co-treatment of HepG2 cells with cisplatin (2 µg/ml) and ginkgol C17:1 (0, 20, 40 and 80 µg/ml) for 24 h, western blot analysis was performed to determine the expression of AMPK, p-AMPK (Thr172), ULK1 and p-ULK1 (Ser555). (B) Following treatment of cells with cisplatin (2 µg/ml) with or without ginkgol C17:1 (40 µg/ml) and compound C (8 µg/ml) for 24 h, western blot analysis was performed to measure the expression of p-AMPK (Thr172), p-ULK1 (Ser555), Beclin-1, LC3I/II, Bax and Bcl-2. AMPK, AMP-activated protein kinase; p-, phosphorylated; LC3, light chain 3; Bcl-2, B-cell lymphoma 2; Bax, Bcl-2-associated X protein.