Figure 2.

Loperamide inhibits the growth of primary leukemia cells from patients in a concentration-dependent manner. (A) A representative image of Wright-Giemsa stain of primary leukemia cells from ALL-P1 and AML-P1 (magnification, ×400). (B) Cell viability of primary cells from ALL-P1 and AML-P1 treated with various concentrations of loperamide for 24 h was measured by the MTT assay. (C) Cell viability of primary cells from ALL and AML patients treated with various concentrations of loperamide for 24 h was measured by the MTT assay. (D) IC₅₀ values of primary cells from ALL and AML patients treated with loperamide for 24 h. ALL, acute lymphocytic leukemia; AML, acute myeloid leukemia; ALL-P1, acute lymphocytic leukemia-patient 1; AML-P1, acute myeloid leukemia-patient 1; IC₅₀, half-maximal inhibitory concentration.