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The ATM-Chk2 signaling pathway is activated in leukemia cells treated by loperamide. Immunoblotting of Molt-4, Thp1, ALL-P1 and AML-P1 cells treated with various concentrations of loperamide for 24 h. ATM, ataxia telangiectasia mutated serine/threonine kinase; Chk2, checkpoint kinase 2; p, phosphorylated; acute lymphocytic leukemia-patient 1; AML-P1, acute myeloid leukemia-patient 1.
