Figure 5. Correlative presentation of age-dependent changes of ⁶⁴Cu uptake (left panel) and ¹⁸F-FDG uptake (right panel) determined using longitudinal PET analysis.

The figures demonstrate a significantly different time course of ⁶⁴Cu and ¹⁸F-FDG uptake in the brain regions across the life span, indicating variable changes of copper fluxes and glucose metabolism in brain aging. Regions were shown for whole brain (WB), olfactory bulb (OB), basal ganglia (BG), posterior cortex (PC), and hippocampus (HC). Error bars represent SD; %ID/g, percentage of injected dose per gram tissue.