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. 2018 Feb 1;9(1):109–118. doi: 10.14336/AD.2017.1025

Table 1.

Whole body biodistribution of 64Cu (mean ± SD %ID/g) in C57BL/6 mice orally administered with 64CuCl2 by a longitudinal PET/CT.

5 months (22 weeks) 13 months (59 weeks) 26 months (104 weeks)
2 h 24 h 2 h 24 h 2 h 24 h
Liver 1.15 ± 0.38 1.73 ± 0.38 1.25 ± 0.35 1.35 ± 0.07 2.13 ± 1.10 1.53 ± 0.41
heart 0.18 ± 0.08** 0.43 ± 0.07* 0.24 ± 0.01 0.29 ± 0.01* 0.50 ± 0.26** 0.56 ± 0.12
Muscle 0.06 ± 0.02 0.05 ± 0.05 0.06 ± 0.01 0.02 ± 0.02 0.09 ± 0.03 0.12 ± 0.12
Brain 0.11 ± 0.02 0.11 ± 0.06 0.14 ± 0.01 0.17 ± 0.05 0.12 ± 0.03 0.14 ± 0.06
Kidneys 0.53 ± 0.18 0.95 ± 0.13* 0.90 ± 0.42 0.81 ± 0.07 0.70 ± 0.53 0.48 ± 0.15*
Lungs 0.22 ± 0.08 0.44 ± 0.05 0.28 ± 0.03 0.36 ± 0.01 0.42 ± 0.31 0.46 ± 0.04

mean ± SD %ID/g, percentage of injected dose per gram of tissue

*

p < 0.05;

p < 0.05 for heart and kidney tracer concentration at 24h PO

**

p < 0.05 for heart at 2h PO.