Table 2.

⁶⁴Cu uptake (mean ± SD %ID/g) in brains of C57BL/6 mice orally administered with ⁶⁴CuCl₂ measured by PET at 24h PO.

	5 months	13 months	26 months
Olfactory bulb	0.17 ± 0.06	0.26 ± 0.09	0.18 ± 0.04
Frontal cortex	0.17 ± 0.14	0.13 ± 0.02	0.17 ± 0.09
Posterior cortex	0.11 ± 0.05	0.12 ± 0.02	0.12 ± 0.05
Hippocampus	0.18 ± 0.05	0.19 ± 0.01	0.14 ± 0.02
Basal ganglia	0.16 ± 0.06	0.20 ± 0.02*	0.09 ± 0.03*
Thal/Hypothal	0.23 ± 0.10✝	0.21 ± 0.06*	0.11 ± 0.03*✝
Mid-brain	0.12 ± 0.03	0.11 ± 0.01	0.12 ± 0.02
Brain stem	0.12 ± 0.01✝**	0.20 ± 0.04**	0.19 ± 0.01✝
Cerebellum	0.12 ± 0.04	0.12 ± 0.01	0.15 ± 0.12

Thal, Thalamus; Hypothal, Hypothalamus; mean ± SD %ID/g, percentage of injected dose per gram.

^*p < 0.05 for organs between 13 and 26 months.

^✝p < 0.05 for organs between 5 and 26 months.

^**p < 0.05 for organs between 5 and 13 months