Table1.

the miRNAs involved in regulating age-related hearing loss.

miRNA	Expression with aging	Possible target	Inference
let-7 family	downregulated	Tnfsf10/Caspase3/Birc5	Regulate dedifferentiation, promote hair cells regeneration
miRNA-183 family	downregulated	Slc26a5 (prestin)/ Gfi1/ Pitpnm1/ Ocm (oncomodulin) /Ptprq	Promote hair cell differentiation and maturation.
miRNA-34 family	upregulated	P53/E74A	Lead to cell-cycle arrest and apoptosis/protect neural cell in the neuro-degenerative disease
miR-200c, miR-29a and miR-17	upregulated	PTPN11/IGF-1/PIK3R1	Enhance sensory and neural cell survival and differentiation
miR-124	downregulated	Dicer1	Maintain normal neuronal functions and normal audition
miR-376	downregulated	phosphoribosyl pyrophosphate synthetase 1 (PRPS1)	Regulate the development of the ganglia and sensory epithelia in the embryonic inner ear; keep normal function of spiral ganglion neurons and cells in the cochlear
miR-15a, miR-18a	downregulated	Slc12a2/Cldn12/Bdnf	Regulate and control inner ear tissue differentiation and maintenance
miR-181a	downregulated	P27	Result in the production of new hair cells, and play an important role in auditory hair cell proliferation and regeneration
miR-29b	upregulated	SIRT1/PGC-1α	Induce cochlear hair cell apoptosis