Table 2.
Drug interaction of NSAIDs and commonly used medications.
Medication | Interactions |
---|---|
Antiplatelets (aspirin, clopidogrel) | Increases risk of GI bleeding |
Angiotensin-converting-enzyme inhibitor (ACEI) and Angiotensin Receptor Blockers (ARB) | Increases in blood pressure by attenuating antihypertensive effects |
Beta blockers | Increases in blood pressure by attenuating antihypertensive effects |
Calcium antagonists | Increases in blood pressure by attenuating antihypertensive effects |
Corticosteroids | Increases risk of GI bleeding |
Digitalis glycosides | Increase serum digoxin level |
Diuretics | Increases in blood pressure by attenuating antihypertensive effects |
Methotrexate | NSAIDs reduce renal excretion of methotrexate, causing methotrexate toxicity. |
Selective serotonin reuptake inhibitors (SSRIs) | Increases risk of GI bleeding |
Warfarin and other anticoagulants | Increases risk of GI bleeding |