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. 2018 Feb 1;9(1):143–150. doi: 10.14336/AD.2017.0306

Table 2.

Drug interaction of NSAIDs and commonly used medications.

Medication Interactions
Antiplatelets (aspirin, clopidogrel) Increases risk of GI bleeding
Angiotensin-converting-enzyme inhibitor (ACEI) and Angiotensin Receptor Blockers (ARB) Increases in blood pressure by attenuating antihypertensive effects
Beta blockers Increases in blood pressure by attenuating antihypertensive effects
Calcium antagonists Increases in blood pressure by attenuating antihypertensive effects
Corticosteroids Increases risk of GI bleeding
Digitalis glycosides Increase serum digoxin level
Diuretics Increases in blood pressure by attenuating antihypertensive effects
Methotrexate NSAIDs reduce renal excretion of methotrexate, causing methotrexate toxicity.
Selective serotonin reuptake inhibitors (SSRIs) Increases risk of GI bleeding
Warfarin and other anticoagulants Increases risk of GI bleeding