Table 2.

Drug interaction of NSAIDs and commonly used medications.

Medication	Interactions
Antiplatelets (aspirin, clopidogrel)	Increases risk of GI bleeding
Angiotensin-converting-enzyme inhibitor (ACEI) and Angiotensin Receptor Blockers (ARB)	Increases in blood pressure by attenuating antihypertensive effects
Beta blockers	Increases in blood pressure by attenuating antihypertensive effects
Calcium antagonists	Increases in blood pressure by attenuating antihypertensive effects
Corticosteroids	Increases risk of GI bleeding
Digitalis glycosides	Increase serum digoxin level
Diuretics	Increases in blood pressure by attenuating antihypertensive effects
Methotrexate	NSAIDs reduce renal excretion of methotrexate, causing methotrexate toxicity.
Selective serotonin reuptake inhibitors (SSRIs)	Increases risk of GI bleeding
Warfarin and other anticoagulants	Increases risk of GI bleeding