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. 2018 Feb 1;9(1):66–76. doi: 10.14336/AD.2017.0426

Figure 3. The activity of AMPK induced by high glucose and apelin in NRCMs.

Figure 3.

(A) Cells were separately treated with 30 mM glucose for 7.5 min, 15 min, 30 min and 60 min. The p-AMPKα/AMPKα ratio declined significantly after high glucose treatment for 7.5 min. (B) The phosphorylation of AMPKα increased after the administration of apelin-13 for 30min. (C) Cells were pre-treated with 30 mM glucose for 24h, and the level of pAMPKα/AMPKα increased at 30 min after adding apelin. CON: normal glucose (5.5 mM); HG: high glucose (30 mM); APLN: apelin-13 (100 nM). *P<0.05, **P<0.01, ***P<0.001. Data are the mean ± SD.