Table 1.
Characteristics of ESCC patients and tissues stratified by HPV status
| Parameter | All
analyzed (N=133)a |
Valid (N=118)b |
HPV
DNA− (N=108)c |
HPV DNA+ (N=10)d |
p-valuee | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | (%) | N | (%) | N | (%) | N | (%) | |||
| Gender | ||||||||||
| Male | 82 | (65) | 71 | (64) | 68 | (67) | 3 | (30) | 0.034 | |
| Female | 44 | (35) | 40 | (36) | 33 | (33) | 7 | (70) | ||
| No data | 7 | 7 | 7 | 0 | ||||||
| Age (years) | ||||||||||
| Median | 62 | 61 | 61 | 61 | ||||||
| Alcohol use | ||||||||||
| Ever drinker | 48 | (38) | 42 | (38) | 37 | (37) | 5 | (50) | 0.502 | |
| Never | 77 | (62) | 68 | (62) | 63 | (63) | 5 | (50) | ||
| No data | 8 | 8 | 8 | 0 | ||||||
| Tobacco use | ||||||||||
| Currentf | 58 | (46) | 53 | (48) | 48 | (48) | 5 | (50) | 1.000 | |
| Former g | 19 | (15) | 15 | (14) | 14 | (14) | 1 | (10) | ||
| Never | 48 | (39) | 42 | (38) | 38 | (38) | 4 | (40) | ||
| No data | 8 | 8 | 8 | 0 | ||||||
| Other: hot teag | ||||||||||
| Warm or lukewarm | 19 | (48) | 17 | (49) | 16 | (48) | 1 | (50) | 1.000 | |
| Hot | 15 | (38) | 12 | (34) | 11 | (33) | 1 | (50) | ||
| Very hot | 6 | (15) | 6 | (17) | 6 | (18) | 0 | (0) | ||
| No data | 93 | 83 | 75 | 8 | ||||||
| Histology | ||||||||||
| Keratinizing | 121 | (97) | 114 | (97) | 104 | (96) | 10 | (100) | 1.000 | |
| Basaloid | 3 | (2) | 3 | (3) | 3 | (3) | 0 | (0) | ||
| Mixed form | 1 | (1) | 1 | (1) | 1 | (1) | 0 | (0) | ||
| NA | 8 | 0 | 0 | 0 | ||||||
| p16INK4a status (IHC) | ||||||||||
| Negative | 111 | (94) | 111 | (94) | 102 | (94) | 9 | (90) | 0.471 | |
| Positive | 7 | (6) | 7 | (6) | 6 | (6) | 1 | (10) | ||
| NA | 15 | 0 | 0 | 0 | ||||||
a
All tumor tissues analyzed. Tumor tissues that are:
b
valid in molecular/immunohistochemical analyses,
c
HPV DNA−/RNA−,
d
HPV DNA+ only (N=9) or DNA+/RNA+ (N=1).
e
Fisher’s exact test for differences in proportions of HPV DNA− and HPV DNA+ cases.
f
Smoking within 5 years of the interview.
g
Quit smoking prior to 5 years before the interview.
h
Information about hot tea consummation was available for ESCC patients from Iran only.
NA - not analyzable