Table 3.

Trends of hazard ratios of head and neck cancers for increasing waist-to-hip ratio and body mass index (BMI) at different ages in the NIH-AARP Diet and health Study¹

		Total head and neck cancers	Oral cavity cancer	Oro- and hypopharynx cancer	Laryngeal cancer
Per 5 unit increase in baseline BMI (kg/m2)	All	0.89 (0.79–0.99)	0.87 (0.74–1.03)	0.71 (0.53–0.95)	0.98 (0.81–1.18)
	Never-smokers	0.98 (0.76–1.26)	0.95 (0.69–1.32)	0.63 (0.29–1.36)	1.54 (0.86–2.75)
	Former smokers	0.94 (0.80–1.10)	0.91 (0.72–1.16)	0.92 (0.63–1.34)	1.02 (0.78–1.35)
	Current smokers	0.76 (0.63–0.93)	0.70 (0.50–0.98)	0.44 (0.26–0.76)	0.90 (0.67–1.21)
	Interaction p value	0.04	0.06	0.21	0.16
Per 0.1 unit increase in waist-to-hip ratio	All	1.16 (1.03–1.31)	1.40 (1.17–1.67)	0.87 (0.63–1.20)	1.10 (0.89–1.35)
	Never-smokers	1.08 (0.79–1.47)	1.31 (0.89–1.92)	0.38 (0.16–0.94)	0.90 (0.42–1.93)
	Former smokers	1.14 (0.95–1.37)	1.57 (1.22–2.01)	0.58 (0.36–0.91)	1.09 (0.80–1.51)
	Current smokers	1.25 (1.02–1.54)	1.25 (0.89–1.75)	1.96 (1.22–3.16)	1.16 (0.84–1.59)
	Interaction p value	0.80	0.40	0.05	0.27

BMI = body mass index; WHR = waist-to-hip ratio.

¹Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI). Risk estimates adjusted for age, sex, marital status, cigarette smoking, education, ethnicity, alcohol consumption, physical activity, and fruit and vegetable intake.