Table 3.

Cumulative Probability of Pregnancy Loss and Hazard Ratios by Occurrence of Signs and Symptoms Each Week Following Positive Pregnancy Test Among Women in the LIFE Study, Michigan and Texas, USA, 2005–2009

	Probability of loss (95% confidence interval)		Hazard Ratio (95% confidence interval)
	Presence of symptom	Absence of symptom	Presence vs. absence of symptom
Any bleeding
Week 1	0.6 (0.5, 0.8)	0.2 (0.2, 0.3)	6.2 (3.8, 10.2)
Week 2	0.3 (0.2, 0.5)	0.2 (0.1, 0.2)	2.3 (1.2, 4.3)
Week 3	0.2 (0.1, 0.3)	0.1 (0.1, 0.2)	1.5 (0.8, 2.8)
Week 4	0.2 (0.1, 0.3)	0.1 (0.1, 0.2)	1.6 (0.9, 2.8)
Week 5	0.1 (0.0, 0.2)	0.1 (0.1, 0.2)	0.8 (0.4, 1.7)
Light/moderate/heavy bleeding
Week 1	0.8 (0.6, 1.0)	0.2 (0.2, 0.3)	8.7 (4.7, 16.0)
Week 2	0.4 (0.2, 0.6)	0.2 (0.1, 0.2)	3.0 (1.4, 6.4)
Week 3	0.2 (0.0, 0.4)	0.2 (0.1, 0.2)	1.4 (0.5, 3.8)
Week 4	0.2 (0.1, 0.4)	0.1 (0.1, 0.2)	1.4 (0.6, 3.2)
Week 5	0.1 (0.0, 0.2)	0.1 (0.1, 0.2)	0.6 (0.2, 2.2)
Moderate/heavy bleeding
Week 1	0.8 (0.6, 1.0)	0.2 (0.2, 0.3)	8.3 (4.2, 16.4)
Week 2	0.6 (0.3, 0.9)	0.2 (0.1, 0.2)	4.7 (2.0, 10.7)
Week 3	0.2 (0.0, 0.5)	0.2 (0.1, 0.2)	1.4 (0.3, 6.5)
Week 4	0.1 (0.0, 0.3)	0.1 (0.1, 0.2)	0.9 (0.2, 3.2)
Week 5	0.4 (0.0, 0.7)	0.1 (0.1, 0.2)	2.8 (0.7, 11.4)
Any nausea and/or vomiting
Week 1	0.3 (0.2, 0.4)	0.2 (0.1, 0.3)	1.3 (0.9, 2.0)
Week 2	0.2 (0.1, 0.2)	0.2 (0.2, 0.3)	0.6 (0.4, 1.0)
Week 3	0.1 (0.1, 0.2)	0.3 (0.2, 0.4)	0.5 (0.3, 0.7)
Week 4	0.1 (0.1, 0.1)	0.3 (0.2, 0.5)	0.4 (0.2, 0.6)
Week 5	0.1 (0.1, 0.1)	0.2 (0.1, 0.4)	0.3 (0.2, 0.5)
Any vomiting
Week 1	0.4 (0.2, 0.6)	0.2 (0.1, 0.3)	1.7 (0.8, 3.6)
Week 2	0.3 (0.1, 0.4)	0.2 (0.2, 0.3)	1.0 (0.5, 2.2)
Week 3	0.1 (0.0, 0.2)	0.3 (0.2, 0.4)	0.3 (0.1, 0.8)
Week 4	0.0 (0.0, 0.1)	0.3 (0.2, 0.5)	0.1 (0.0, 10.8)
Week 5	0.1 (0.0, 0.1)	0.2 (0.1, 0.4)	0.2 (0.1, 0.7)
Any nausea a
Week 1	0.3 (0.2, 0.4)	0.2 (0.1, 0.3)	1.2 (0.8, 1.9)
Week 2	0.1 (0.1, 0.2)	0.2 (0.2, 0.3)	0.5 (0.3, 0.9)
Week 3	0.1 (0.1, 0.2)	0.3 (0.2, 0.4)	0.5 (0.3, 0.8)
Week 4	0.1 (0.1, 0.2)	0.3 (0.2, 0.5)	0.4 (0.3, 0.7)
Week 5	0.1 (0.0, 0.2)	0.2 (0.1, 0.4)	0.4 (0.2, 0.7)
Any cramping
Week 1	0.3 (0.2, 0.4)	0.2 (0.1, 0.3)	1.8 (1.2, 2.7)
Week 2	0.2 (0.1, 0.2)	0.2 (0.1, 0.3)	0.9 (0.6, 1.5)
Week 3	0.1 (0.1, 0.1)	0.2 (0.1, 0.3)	0.5 (0.3, 0.9)
Week 4	0.1 (0.1, 0.2)	0.2 (0.1, 0.2)	0.6 (0.3, 1.0)
Week 5	0.1 (0.0, 0.1)	0.2 (0.1, 0.2)	0.4 (0.2, 0.7)

^aNausea, but not vomiting, during the week