Table 4.

Cumulative Probability of Pregnancy Loss and Hazard Ratios by Occurrence of Combinations of Signs and Symptoms Each Week Following Positive Pregnancy Test Among Women in the LIFE Study, Michigan and Texas, USA, 2005–2009

	Probability of loss (95% confidence interval)	Hazard Ratio (95% confidence interval)
		Reference includes women with no symptoms or with spotting only	Reference includes women with no symptoms
No symptoms a
Week 1	0.2 (0.1, 0.4)	1.0 (Reference)	1.0 (Reference)
Week 2	0.3 (0.2, 0.4)	1.0 (Reference)	1.0 (Reference)
Week 3	0.2 (0.1, 0.3)	1.0 (Reference)	1.0 (Reference)
Week 4	0.3 (0.2, 0.5)	1.0 (Reference)	1.0 (Reference)
Week 5	0.2 (0.1, 0.3)	1.0 (Reference)	1.0 (Reference)
Cramping only
Week 1	0.2 (0.0, 0.3)	0.5 (0.1, 2.0)	0.5 (0.1, 2.2)
Week 2	0.2 (0.1, 0.3)	0.6 (0.2, 1.3)	0.6 (0.3, 1.4)
Week 3	0.2 (0.0, 0.3)	0.4 (0.1, 1.7)	0.6 (0.2, 2.2)
Week 4	0.2 (0.0, 0.4)	1.0 (0.4, 2.7)	0.6 (0.1, 2.8)
Week 5	0.3 (0.0, 0.5)	0.9 (0.2, 3.5)	1.0 (0.2, 4.0)
Nausea/vomiting only
Week 1	0.2 (0.0, 0.3)	0.6 (0.2, 1.7)	0.7 (0.2, 1.9)
Week 2	0.1 (0.1, 0.2)	0.4 (0.2, 0.9)	0.5 (0.2, 1.1)
Week 3	0.2 (0.1, 0.2)	0.6 (0.4, 1.0)	0.7 (0.4, 1.1)
Week 4	0.1 (0.0, 0.2)	0.4 (0.2, 0.7)	0.4 (0.2, 0.8)
Week 5	0.1 (0.0, 0.2)	0.4 (0.2, 0.9)	0.4 (0.2, 0.9)
Nausea/vomiting + cramping
Week 1	0.2 (0.1, 0.3)	0.9 (0.6, 1.6)	0.9 (0.5, 1.5)
Week 2	0.1 (0.1, 0.2)	0.5 (0.2, 0.9)	0.5 (0.3, 1.0)
Week 3	0.1 (0.0, 0.1)	0.2 (0.1, 0.6)	0.3 (0.1, 0.7)
Week 4	0.1 (0.0, 0.1)	0.3 (0.1, 0.6)	0.3 (0.1, 0.7)
Week 5	0.1 (0.0, 0.1)	0.2 (0.1, 0.5)	0.2 (0.1, 0.6)
Nausea/vomiting + cramping + bleeding
Week 1	0.7 (0.5, 0.9)	5.2 (2.6, 10.5)	4.5 (2.4, 8.5)
Week 2	0.3 (0.1, 0.5)	1.6 (0.7, 3.8)	1.4 (0.6, 3.1)
Week 3	0.1 (0.0, 0.2)	0.5 (0.1, 2.2)	0.4 (0.1, 1.4)
Week 4	0.1 (0.0, 0.3)	0.5 (0.2, 1.8)	0.5 (0.2, 1.5)
Week 5	0.1 (0.0, 0.1)	0.0 (0.0, 229)	0.2 (0.1, 1.0)

^aNo symptoms includes women without any cramping, bleeding, nausea and/or vomiting