Table III.
Pharmacokinetics of dTCApFs on the first day of cycles 1 and 2 (each cycle was 28 days).
| Cycle 1, day 1 | Cycle 2, day 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| dTCApFs dose, mg/m2 | 6 (n=3) | 12 (n=4) | 24 (n=4) | 48 (n=4) | 96 (n=3) | 6 (n=3) | 12 (n=4) | 24 (n=4) | 48 (n=4) | 96 (n=3) |
| AUC0, ng·h/ml | 3,813 | 12,905 | 49,630 | 79,935 | 206,742 | 9,719 | 11,452 | 57,069 | 100,093 | 294,682 |
| Cmax, ng/ml | 1,209 | 6,048 | 14,609 | 18,267 | 32,964 | 1,536 | 6,048 | 14,609 | 22,113 | 32,016 |
| t1/2, h | 2.3 | 2.1 | 3.2 | 4.9 | 6.0 | 2.8 | 2.0 | 3.7 | 4.6 | 8.5 |
AUC, area under the curve; Cmax, maximal plasma concentration; t1/2, plasma half-life.