Table V.
Mean change (%) in serum levels of angiogenic factors and cytokines pre- to post- treatment with dTCApFs.
| dTCApFs dose, mg/m2 | |||||
|---|---|---|---|---|---|
| Factors | 6 (n=3) | 12 (n=3) | 24 (n=3) | 48 (n=3) | 96 (n=5) |
| Angiogenic factors | |||||
| Angiopoietin-1 | +960 | −80 | −77 | −50 | +70 |
| FGF-1 | +120 | −62 | −20 | −27 | +457 |
| FGF-2 | +199 | −74 | −34 | −13 | +44 |
| PDGF-AA | +1,379 | −92 | −79 | −73 | +57 |
| PDGF-BB | +2,271 | −95 | −82 | −78 | +185 |
| VEGF-A | +265 | −47 | −62 | −72 | −2 |
| TGF-β1 | +18 | −80 | −59 | −20 | No data |
| VEGF-D | +117 | −40 | −54 | −63 | +3 |
| Cytokines | |||||
| GM-CSF | +2,173 | −97 | +11 | +5,613 | +974 |
| IL-12-p70 | +469 | −76 | +83 | +477 | +332 |
| IL-2 | No data | −100 | No data | +242 | +577 |
| IL-21 | +100 | −61 | +84 | +1,326 | +29 |
| TNF-α | +4 | −5 | +31 | +74 | +97 |
FGF, fibroblast growth factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin; PDGF, platelet-derived growth factor; TGF, transforming growth factor; VEGF, vascular endothelial growth factor; TNF, tumor necrosis factor.