Table 2.
Significant relationships between cortical thickness and AV-1451 signal.
Concurrent Cross-Sectional Cortical Thickness | Retrospective Longitudinal Cortical Thinning | |||
---|---|---|---|---|
Cortical region | Local tau | Inferior temporal tau | Local tau | Inferior temporal tau |
lh bankssts | t(98)=−2.32 p=0.022# e=−0.205 |
t(98)=−2.60 p=0.011# e=−0.265 |
t(228)=−2.01; p=0.046# e=−0.032 |
- |
rh bankssts | - | t(98)=−2.59 p=0.011# e=−0.251 |
- | - |
rh caudal anterior cingulate | - | - | t(228)=−2.31; p=0.022# e=0.044 |
- |
lh caudal anterior cingulate | t(98)=−3.14 p=0.0023## e=−0.492 |
- | - | - |
lh caudal middle frontal | t(98)=−2.27 p=0.025# e=−0.193 |
t(98) =−2.90; p=0.0047## e=−0.232 |
- | - |
rh caudal middle frontal | - | t(98)=−3.13 p=0.0023## e=−0.214 |
- | - |
lh cuneus | - | - | t(228)=−2.14 p=0.033# e=−0.019 |
- |
lh entorhinal | t(98)=−4.18 p=0.000064* e=−0.440 |
t(98)=−2.22 p=0.029# e=−0.502 |
- | - |
rh entorhinal | t(98)=−3.96 p=0.00014 e=−0.438 |
t(98)=−3.01 p=0.0034## e=−0.708 |
- | - |
lh frontal pole | t(98)=3.30 p=0.0013## e=0.301 |
- | - | - |
lh fusiform | t(98)=−3.36 p=0.0011## e=−0.283 |
t(98)=−2.66 p=0.0091# e=−0.229 |
- | - |
rh fusiform | t(98)=−4.97 p=0.0000029** e=−0.448 |
t(98)=−5.531; p=0.00000027** e=−0.494 |
t(228)=−2.22; p=0.027# e=−0.031 |
t(228)=−3.82 p=0.00017* e=−0.052 |
lh inferior parietal | t(98)=−2.32 p=0.023# e=−0.212 |
t(98)=−2.36; p=0.020# e=−0.172 |
- | - |
rh inferior parietal | t(98)=−2.73 p=0.0075# e=−0.202 |
t(98)=−3.82 p=0.00023* e=−0.265 |
- | - |
lh inferior temporal | t(98)=−2.67 p=0.0090# e=−0.210 |
- | - | - |
rh inferior temporal | t(98)=−3.92 p=0.00016** e=−0.325 |
t(98)=−3.61; p=0.00048* e=−0.326 |
- | - |
lh insula | t(98)=−2.81 p=0.0060## e=−0.395 |
- | - | - |
rh insula | t(98)=−2.30 p=0.023# e=−0.270 |
t(98)=−2.22 p=0.029# e=−0.216 |
- | - |
lh lateral occipital | - | t(98)=−2.29; p=0.024# e=−0.196 |
- | - |
rh lateral occipital | t(98)=−2.09 p=0.039# e=−0.104 |
t(98)=−3.15 p=0.0022## e=−0.235 |
- | - |
rh lateral orbitofrontal | t(98)=−2.15 p=0.034# e=−0.207 |
t(98)=−2.44; p=0.017# e=−0.226 |
||
rh lingual | t(98)=−3.30 p=0.0014## e=−0.178 |
- | - | - |
lh middle temporal | t(98)=−3.71 p=0.00034* e=−0.354 |
t(98)=−3.10 p=0.0025## e=−0.269 |
- | - |
rh middle temporal | t(98)=−4.14 p=0.000075** e=−0.278 |
t(98)=−4.96 p=0.0000029** e=−0.357 |
t(228)=−3.66 p=0.00032* e=−0.043 |
t(228)=−2.18 p=0.030# e=−0.029 |
rh paracentral | t(98)=−2.39 p=0.019# e=−0.201 |
- | - | - |
lh parahippocampal | t(98)=−2.71 p=0.0079# e=−0.377 |
t(98)=−2.77; p=0.0066# e=−0.577 |
- | t(228)=−2.60 p=0.0099# e=−0.049 |
rh parahippocampal | - | t(98)=−2.47 p=0.015# e=−0.411 |
- | t(228)=−1.99 p=0.048# e=−0.041 |
lh pars opercularis | t(98)=−2.80 p=0.0061# e=−0.219 |
- | - | - |
lh pars orbitalis | t(98)=−2.91 p=0.0045## e=−0.239 |
- | - | - |
rh pars orbitalis | t(98)=−2.12 p=0.037# e=−0.207 |
- | - | - |
lh pars triangularis | - | - | - | t(228)=1.98 p=0.049# e=0.036 |
rh pars triangularis | t(98)=−2.52 p=0.013# e=−0.203 |
- | - | t(228)=2.15 p=0.033# e=0.036 |
lh precentral | - | t(98)=−2.05 p=0.043# e=−0.167 |
- | - |
rh precentral | - | t(98)=−2.31 p=0.023# e=−0.190 |
- | - |
rh precuneus | - | t(98)=−2.78 p=0.0066# e=−0.213 |
- | - |
lh rostral anterior cingulate | - | - | - | - |
lh rostral middle frontal | - | - | - | - |
rh rostral middle frontal | - | - | t(228)=3.37; p=0.00090## e=0.041 |
t(228)=2.61 p=.0098# e=0.034 |
rh superior frontal | - | t(98)=−3.12 p=0.0024## e=−0.208 |
- | - |
lh superior parietal | t(98)=−2.12 p=0.037# e=−0.179 |
- | - | |
Rh superior parietal | t(98)=−2.24 p=0.027# e=−0.175 |
- | - | |
lh superior temporal | - | t(98)=−3.23 p=0.0017## e=−0.288 |
- | - |
rh superior temporal | - | t(98)=−2.46 p=0.016# e=−0.192 |
t(228)=−2.85 p=0.0047## e=−0.040 |
- |
lh supramarginal | t(98)=−2.20; p=0.030# e=−0.222 |
t(98)=−2.53 p=0.013# e=−0.191 |
- | - |
rh supramarginal | t(98)=1.98; p=0.050# e=−0.207 |
t(98)=−2.67 p=0.0089# e=−0.220 |
- | - |
lh temporal pole | t(98)=−4.24; p=0.000051** e=−0.535 |
- | - | - |
rh temporal pole | t(98)=−6.40; p=0.000000061** e=−0.640 |
t(98)=−3.46 p=0.00080## e=−0.661 |
t(228)=−3.74 p=0.00023* e=−0.063 |
- |
lh transverse temporal | t(98)=−2.13 p=0.036# e=−0.241 |
- | - | - |
rh transverse temporal | - | - | t(228)=2.37; p=0.018# e=0.036 |
- |
lh hippocampus | - | - | - | - |
lh lateral ventricle | - | - | - | t(226)=2.22 p=0.027# e=525.77 |
lh inferior lateral ventricle (temporal horn) | - | - | - | t(226)=2.14 p=0.034# e=57.879 |
Total cortical gray matter volume | - | t(97)=−2.93; p=0.0042## e=−37295 |
- | - |
Cortical regions are listed in the first column. Left and right hemispheres are abbreviated as 1h and rh, respectively. Bankssts is the banks of the superior temporal sulcus.
Significance is denoted with the following symbols:
p≤0.05
p≤0.005
p≤0.0005
p≤0.00005 (all uncorrected); gray shading – survives FDR correction (local and inferior temporal cross-sectional: p≤0.013; local longitudinal: p≤0.00090; inferior temporal longitudinal: p≤0.00017).