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Bumped kinase inhibitor (BKI) 1369 concentrations in mouse gastrointestinal tissues, plasma and brain tissue after a single oral dose of BKI 1369 at 30 mg/kg of body weight. (A) Gastroplus predicted concentrations of BKI 1369 in gastrointestinal tract tissues. (B) In vivo concentrations of gastrointestinal tract tissues. (C) In vivo brain tissue concentrations and predicted and in vivo plasma concentrations on BKI 1369.
