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Metabolite identification. Adult BALB/c mice orally dosed with bumped kinase inhibitor (BKI) 1369 (60 mg/kg of body weight) yielded two major metabolites based on LC-MS/MS analysis of plasma samples. They were a product of the demethylation of the BKI 1369 methyl-piperidine-methyl group (metabolite 1) or a conversion of the quinoline ethyl ether to a 2-oxy-quinoline (metabolite 2). Each of the metabolites appears to be non-toxic to human cells.
