. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: Int J Parasitol. 2017 Sep 9;47(12):753–763. doi: 10.1016/j.ijpara.2017.08.006

Table 5.

Genotoxicity screening using the 24-well Ames and in vitro micronucleus assays, and cardiotoxicity screening using the Qpatch assay for ether-à-go-go channel activity and the QTiSA-HT assay for contractility, effective refractory period, and threshold excitability of bumped kinase inhibitor 1369.

24-well Ames assay	In vitro micronucleus	Qpatch hERG	Change in contractility from buffer (%)			Change in ERP from buffer (ms)			Change in threshold excitability from buffer (V/cm)
24-well Ames assay	In vitro micronucleus	IC₅₀ (μM)	IC₅₀ (μM)	MSC (μM)	30 μM (% change)	IC₅₀ (μM)	MSC (μM)	30 μM (% change)	IC₅₀ (μM)	MSC (μM)	30 μM (% change)
Negative	Positive	1.51	20	4.17	−57.4	>30	6.68	42.3	>30	9.06	0.7

MSC, minimum significant concentration.