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Rat cardiotoxicity screening of bumped kinase inhibitor 1369.
| IV infusion dose (mg/kg) |
Maximum plasma concentration ± S.D. (μM) |
MAP (% change) |
HR (% change) |
dP/dt@50 (% change) |
|---|---|---|---|---|
| 3 | 0.73 ± 0.7 | −1 | −4 | 3 |
| 10 | 2.62 ± 0.3 | −7 | −10 | −3 |
| 30 | 5.00 ± 0.5 | −12 | −21 | −23 |
A change of ± >15% was considered significant.
MAP, mean arterial pressure; HR, heart rate; dT/dP@50, left ventricular contractility.
