Fig. 2.

Joint-space narrowing (JSN) at year 2 by baseline pain severity level of individual and total WOMAC pain scores of target (a)- and non-target (b) knees. Data on JSN are mixed-model least-square means (standard error) adjusted for KL-score, BMI, study code, and sex. Pain severity is divided into quintile subgroups of normalized maximum possible score ranging from 0 mm (least possible pain) to 100 mm (worst imaginable pain for each WOMAC pain category. The number of observations (knees) in each category are shown in the table below the figures. Sub-groups with less than 10 observations, marked with * in the table, are excluded from the figure. Target knee. NT: Non-target knee. WOMAC: Western Ontario and McMaster’s Universities Arthritis Index. Error bars are SEM