Table 2.
Clinical Characteristics of NPM1-mutated AML Patients with Low or High INPP4B Expression
| Characteristics | Low INPP4B (n = 29) | High INPP4B (n = 9) |
|---|---|---|
| Sex | ||
| Female | 15 | 6 |
| Male | 14 | 3 |
| Age, years | ||
| Median, range | 52.93 (21–81) | 50.56 (21–82) |
| WBC, ×10 9 /L | ||
| Median, range | 61.58 (5–137) | 49.78 (1–134) |
| Platelets, ×10 9 /L | ||
| Median, range | 53.86 (8–174) | 63.56 (11–232) |
| Bone marrow blast, % | ||
| Median, range | 78.93 (48–98) | 70.11 (41–95) |
| FAB classification | ||
| M0 | 0 | 1 |
| M1 | 11 | 2 |
| M2 | 3 | 4 |
| M3 | 0 | 0 |
| M4 | 10 | 0 |
| M5 | 5 | 2 |
| M6 | 0 | 0 |
| M7 | 0 | 0 |
| Cytogenetics | ||
| Normal | 27 | 7 |
| Abnormal | 0 | 1 |
| Unknown | 2 | 1 |
| Cytogenetic risk | ||
| Favorable | 0 | 0 |
| Intermediate | 28 | 7 |
| Adverse | 0 | 1 |
| Unknown | 1 | 1 |
| Gene mutations | ||
| FLT3-ITD | 16 | 6 |
| IDH1 | 8 | 0 |
Abbreviations: AML acute myeloid leukemia, WBC white blood cell, FAB classification, French-American-British classification, a classification of acute leukemia produced by three-nation joint collaboration