Table 3.
Genotypic frequencies of G20210A FII polymorphism in patients with colorectal cancer according to clinical and histological parameters.
| Number | G20210A FII | Chi-square Test | ||||
|---|---|---|---|---|---|---|
| GG (%) | GA (%) | AA (%) | P value | |||
| Age | 0.14 | 3.90 | ||||
| <45 years | 34 | 35.3 | 58.8 | 5.9 | ||
| ≥45 years | 42 | 40.5 | 40.5 | 19.0 | ||
| Gender | 0.46 | 0.80 | ||||
| male | 40 | 35.0 | 50.0 | 15.0 | ||
| female | 36 | 41.7 | 47.2 | 11.1 | ||
| Time to diagnosis | 0.50 | 1.40 | ||||
| <6 month | 42 | 33.3 | 54.8 | 11.9 | ||
| ≥6 month | 34 | 44.1 | 41.2 | 14.7 | ||
| Family Antecedent | 0.70 | 2.18 | ||||
| CRC | 12 | 33.3 | 58.3 | 8.3 | ||
| Other cancers | 5 | 60.0 | 20.0 | 20.0 | ||
| No family history | 59 | 37.3 | 49.2 | 13.6 | ||
| Localization | 0.14 | 12.25 | ||||
| Right Colon | 14 | 64.3 | 28.6 | 7.1 | ||
| Transverse Colon | 2 | 50.0 | 50.0 | 0 | ||
| Left Colon gauche | 16 | 25.0 | 62.5 | 12.5 | ||
| Sigmoid | 28 | 42.9 | 50.0 | 7.1 | ||
| Rectum | 16 | 18.8 | 50.0 | 31.2 | ||
| Histology component | 0.60 | 1.01 | ||||
| ADK simple | 59 | 37.3 | 47.5 | 15.3 | ||
| ADK colloid mucinous | 17 | 41.2 | 52.9 | 5.9 | ||
| Differentiation | 0.27 | 5.16 | ||||
| Well | 27 | 40.7 | 37.0 | 22.2 | ||
| Moderate | 36 | 33.3 | 55.6 | 11.1 | ||
| Poor | 13 | 46.2 | 53.8 | 0 | ||
| Stage | 0.13 | 9.90 | ||||
| Stage I | 11 | 45.5 | 27.3 | 27.3 | ||
| Stage II | 21 | 38.1 | 57.1 | 4.8 | ||
| Stage II | 28 | 39.3 | 39.3 | 21.4 | ||
| Stage IV | 16 | 31.2 | 68.8 | 0 | ||
*
Statistically significant