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. Author manuscript; available in PMC: 2018 Nov 10.
Published in final edited form as: Circ Res. 2017 Oct 13;121(11):1237–1250. doi: 10.1161/CIRCRESAHA.117.311367

Figure 2. Identification of Class I enhancers in human iPSCs and somatic cells by chromatin marks (H3K4me1 and H3K27ac).

Figure 2

(A) Cell type-specific enrichment of active enhancer mark H3K27ac. (B) Ubiquitous H3K4me1 enrichment in the same genomic loci surveyed in (A). (C–D) Histone acetyltransferase p300 and RNA Pol II were enriched in a similar pattern as active enhancer mark H3K27ac across multiple cell types. (E) Categorization of two classes of enhancers according to H3K4me1 and H3K27ac enrichment. (F) An example of a putative Class I enhancer in CSNK1E locus. (G) Impact of putative Class I enhancers on cell type-specific expression of the nearest genes in cluster 6.