Skip to main content
. Author manuscript; available in PMC: 2018 Nov 10.
Published in final edited form as: Circ Res. 2017 Oct 13;121(11):1237–1250. doi: 10.1161/CIRCRESAHA.117.311367

Figure 3. Class II enhancers are identified by cell type-specific H3K4me1 enrichment.

Figure 3

(A–B) Cell type-specific enrichment of H3K27ac and H3K4me1 in Class II enhancers. (C–D) In Class II enhancers, the genomic distribution of p300 and RNA Pol II was positively correlated with those of H3K27ac and H3K4me1. (E) Cell type-specific enrichment of H3K4me1 and H3K27ac in the upstream region of LIPF. (F) Transcriptional abundance was influenced by the cell type-specific enhancer activity in the cluster 6 genes. (G–H) Motif enrichment analysis identified binding sites for transcription factors relevant to stem cell pluripotency (OCT4/SOX2/NANOG) in cluster 1 and endothelial development (ETV2/FLI1/ETS1) in cluster 4 of Class II enhancers.