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. 2018 Jan 17;15:20. doi: 10.1186/s12974-017-1041-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Detection efficiency of metabolites in CSF and selection for subsequent analyses. The number of detectable metabolites per analyte class is stated on the y-axis. Bars indicate the number of analytes in a given class detected >LOD in all samples according to four categories as indicated by the fill patterns: detected in all samples (“100%”), >75% of samples (“75–99%”), <75% of samples (“<75%”), and in none of the samples (“0%”). The 88 metabolites detected in 75–100% of all samples were used for subsequent analysis