Table 3.
Comparison of leukocyte count against metabolite biomarkers to detect CNS infection in VZV reactivation
| Sensitivity | Specificity | PPV | NPV | AUC (95% CI) | P valuea | |
|---|---|---|---|---|---|---|
| Leukocyte count | 0.80 | 0.70 | 0.57 | 0.88 | 0.77 (0.64–0.91) | 0.003 |
| SM C16:1 | 0.73 | 0.77 | 0.61 | 0.85 | 0.81 (9.68–0.94) | 0.001 |
| Glycine | 0.80 | 0.70 | 0.57 | 0.88 | 0.78 (0.64–0.93) | 0.002 |
| lysoPC a C26:1 | 0.93 | 0.62 | 0.56 | 0.95 | 0.79 (0.66–0.93) | 0.002 |
| PC ae C34:0 | 0.53 | 1.00 | 1.00 | 0.80 | 0.84 (0.71–0.97) | < 0.0001 |
Values are based on binary comparison of Z. meningoencephalitis vs. the pool of Z. facial and Z. segmental. The metabolite biomarkers correspond to the four best internally validated metabolites (Fig. 4, Table 2)
AUC area under the receiver operating characteristic curve, CI confidence interval, PPV positive predictive value, NPV negative predictive value, PC phosphatidylcholine, SM sphingomyelin
aUncorrected asymptotic P values