Table 3. Summary of major features associated with tuberculosis and disseminated histoplasmosis in context of HIV infection.
| Parameters | Tuberculosis | Histoplasmosis |
|---|---|---|
| Immune suppression | ↓↓ | ↑↑ |
| Pancytopaenia | ↓↓ | ↑↑ |
| Diarrhoea | ↓↓ | ↑↑ |
| Renal function | –– | –– |
| High liver function tests (AST, ALT, γGT, ALP, LDH) | ↓↓ | ↑↑ |
| Hepatosplenomegaly (clinical and ultrasound) | ↓↓ | ↑↑ |
| Inflammatory markers (CRP >70 mg/L) | –– | –– |
| Ferritin and triglyceride | ↓↓ | ↑↑ |
| Systemic involvement (GIT, bone marrow, liver and peripheral blood) | ↓↓ | ↑↑ |
| Disseminated disease | ↓↓ | ↑↑ |
| Respiratory system (clinical and laboratory) | ↑↑ | ↓↓ |
| Central nervous system involvement (clinical and investigation) | –– | –– |
| Skin | ↓↓ | ↑↑ |
––, Similar features; ↓↓, Lower frequency; ↑↑, Higher frequency.