Table 4.
Association between AD Biomarkers and risk of CDR ≥ 0.5 over the Follow-up.
| Baseline CSF biomarkers | Hazard ratio (95% CI) of CDR ≥ 0.5a | |||
|---|---|---|---|---|
|
| ||||
| Unadjusted | P value | Adjustedb | P valueb | |
| Single biomarkerb: | ||||
| High CSF total Tau, ≥ 100 pg/mL | 3.37 (1.29 – 8.80) | 0.01 | 3.52 (1.24 – 10.00) | 0.02 |
| Low CSF Aβ42, ≤ 352 pg/mL | 1.76 (0.71 – 4.37) | 0.22 | 1.85 (0.67 – 5.08) | 0.24 |
| High PIB FLR, ≥ 1.17 | 2.56 (1.03 – 6.33) | 0.04 | 3.09 (1.00 – 9.71) | 0.05 |
| Low FDG PET, ≤ 3.19 | 0.48 (0.16 – 1.44) | 0.19 | 0.35 (0.11 – 1.12) | 0.08 |
| Low hippocampal volume, ≤ 3350 mm3 | 1.77 (0.67 – 4.67) | 0.25 | 1.70 (0.58 – 5.01) | 0.34 |
| Combination of biomarkers: | ||||
| High CSF Tau and low CSF Aβ42 | 4.46 (1.55 – 12.87) | 0.006 | 3.78 (1.19 – 11.99) | 0.02 |
| High CSF Tau and low Hippocampal volume | 2.65 (0.76 – 9.23) | 0.13 | 2.96 (0.73 – 12.00) | 0.13 |
| High CSF Tau and High PIB FLR | 2.70 (0.87–8.37) | 0.09 | 2.25 (0.69 – 7.33) | 0.18 |
| Low CSF Aβ42 and high PIB FLR | 2.85 (1.14 – 7.08) | 0.02 | 3.49 (1.12 – 10.89) | 0.03 |
| Low CSF Aβ42 and low hippocampal volume | 4.84 (1.83 – 12.82) | 0.002 | 6.62 (1.71 – 25.58) | 0.006 |
| High PIB FLR and low hippocampal volume | 4.10 (1.55–10.81) | 0.004 | 5.27 (1.45 – 19.12) | 0.01 |
a
Highest or lowest quartile compared to the 3 other quartiles.
b
High CSF total Tau and high PIB FLR correspond to highest quartile; low CSF Aβ42, FDG PET and hippocampal volume correspond to lowest quartile.
c
Adjusted for age, gender, MMSE score, APOE ε4, and years of education