. Author manuscript; available in PMC: 2018 Jan 18.

Published in final edited form as: J Alzheimers Dis. 2017;60(4):1451–1459. doi: 10.3233/JAD-170511

Table 5.

General Linear Mixed Models Estimates of the Relationship between Baseline Biomarkers and MMSE Score at Baseline and over the Follow-up.

Biomarkers	Estimates (SE)^a	P value^a
Baseline MMSE
CSF Aβ1-42	−0.01 (0.10)	0.91
CSF Tau	−0.10 (0.09)	0.28
CSF p-Tau 181	−0.13 (0.09)	0.16
MRI hippocampal volume	0.20 (0.13)	0.13
PIB FLR region	−0.16 (0.13)	0.21
FDG temporoparietal region	−0.88 (0.57)	0.58
Change in MMSE per year
CSF Aβ1-42, continuous, x time	0.008 (0.03)	0.80
CSF Tau x time	−0.066 (0.03)	0.02
CSF p-Tau 181 x time	−0.042 (0.03)	0.14
MRI hippocampal volume x time	−0.001 (0.03)	0.99
PIB FLR region x time	−0.049 (0.04)	0.18
FDG temporoparietal region	0.009 (0.04)	0.82

MTL: medial temporal lobe; FLR: Frontal, lateral parietal and lateral temporal, and retrosplenial.

Standardized estimates of mixed models, adjusted on age, gender, APOE ε4, and years of education