Table 1. Key residues, numbered based on aligned V3 loop sequences (Figure A in S1 File) that interact with ligands based on fingerprinting analysis (Figures L-Q in S1 File).

Residues identified interact with > 50% of ligands and >40% if denoted with an asterisk.

gp120	IC50 (ng/mL)[13]	H-Bond	Hydrophilic	Hydrophobic	Backbone
2B4C	NA	R3, R9*	Q6, T8	P4, I32, P438	N5, R440
92UG037	750		R3, T8, R9, Q34, Q401	P4, I28, I32, P399	N5, N6, D31, I400
BaL	230		R3, N6, T8, R9, Q34, R405	P4, I28, I32, P403	N5, N7*, G26*, I404 G406
IIIb	95	T8, R9	N6, S408	I12, V23, I29, M32	N5, T24, I25, G26
JR-CSF	760		N6, T8, R9, E27, K401	I28, I32	T24, G26
YU2	NA	R396	R3, N5, T8	I28, I32, P393*	G26, P394, I395

NA = not available.