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. Author manuscript; available in PMC: 2018 Jan 18.
Published in final edited form as: Clin Sci (Lond). 2017 Jun 30;131(14):1669–1688. doi: 10.1042/CS20160897

Figure 2. Plasma glutathione/glutathione disulfide (GSH/GSSG) and cysteine/cystine (Cys/CySS) redox potentials in humans.

Figure 2

Results show that these redox couples are not equilibrated and become oxidized with age [23,32,78]. The lack of equilibration of these systems implied that protein thiol/disulfide systems also exist in a non-equilibrium state, and this was subsequently confirmed (see text). Cross–sectional and longitudinal studies in humans showed oxidation of thiol/disulfide systems with age, suggesting that progressive changes occur due to lifelong interaction of individuals with environment. Eh is the steady-state redox potential calculated from the measured concentrations using the Nernst equation [78].