Table 2.

Model parameters.

Parameter	Meaning	Value	Ref.
R, RN	cell radius and cell nuclear radius	9.953 e 5.295 µm	29
RA	action radius	1.214R	29
cccr	cell-cell repulsion coefficient	5η µm/min	estimated
γ	cell-cell adhesion scale	0.0488836	29
$M_{\mathit{\text{out}}}^{\mathit{\text{max}}}$	maximum number of cells that leave the domain	1500	estimated
σB	oxygen concentration at the boundary	0.6	estimated
σH	hypoxic threshold	0.2	29
αA	𝒬 → 𝒜 transition intensity	0.0012728 h−1	29
τP	cell cycle time	18 h	29
τG1	G1 cell cycle phase time	9 h	29
τA	apoptosis time	8.6 h	29
τNL	lysing time	6 h	29
τC	necrosis time	360 h	29
τM	maximum motility time	1 h	estimated
χ	haptotaxis coefficient	25η µm/min	estimated
D	oxygen diffusion coefficient	1000 µm2/h	29
λ	oxygen uptake rate of tumor cells	0.1 min−1	29
λb	oxygen uptake rate of healthy cells	0.01λ	29
Degf	EGF diffusion coefficient	1 × 10−12 µm2/h	estimated
Fegf	EGF concentration secreted by quiescent cells	2.65 nM/s	42
TPLC	threshold for proliferation advantage	−1 × 10−4 nM/s	estimated
TERK	threshold for migration advantage	1.2 × 10−5 nM/s	estimated