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. 2018 Jan 18;14(1):e1007106. doi: 10.1371/journal.pgen.1007106

Fig 8. Mutation of the calcium chaperone crt-1 sensitises to 6-OHDA-induced dopaminergic neurodegeneration.

Fig 8

(A) Effect of mutations in crt-1 mutation on dopaminergic neurodegeneration after treatment with 10 mM, (B) 25 mM and (C) 50 mM 6-OHDA. Error bars = SEM of 2–3 biological replicates with 90–130 animals per strain and concentration. Total number of animals per strain = 200–360 (****p<0.0001, *p<0.05; G-Test). (D) crt-1 mRNA level analysis after 1h of 6-OHDA treatment in wild-type and mutant L1 stage larvae. (E) crt-1 mRNA level analysis in mutant L1 stage larvae as compared to wild-type animals under control conditions (treatment with H2O instead of 6-OHDA). (D) and (E) The data are normalised to the control gene Y45F10D.4. The average and the respective values for 5 biological replicates (biorep a-e) are indicated. Error bars = SEM of 5 biological replicates (n.s. p>0.05; two-tailed t-test).