Fig 5. Classical complement pathway activity in female LV in aging and aging plus RLX.

The classical complement cascade can result in an opsonization, or marking of cells for phagocytosis, and lysis of bacteria. It can also result in an augmented inflammatory response. A. Effect of aging on complement component activation. B. Effect of RLX on reversal of complement activity. Red boxes indicate significant alterations of specific complement components. Red and blue thermometer markers next to specific components indicate increased and decreased component expression, respectively. For key describing complement components, see https://portal.genego.com/help/MC_legend.pdf.