Fig 5. vtRNA1-1 induced mitoxantrone independent with the existence of MVP.
(A) The efficiency of MVP or vtRNA1-1 knockdown was detected by semiquantitative western blot or qRT-PCR. (B) DOX sensitivity to MCF-7 cells with or without vtRNA1-1 knockdown was detected. (C) Immunofluorescence imaging was performed to detect the sub-cellular localization of DOX with or without vtRNA1-1 knockdown.