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. 2018 Jan 18;13(1):e0191363. doi: 10.1371/journal.pone.0191363

Fig 8. Selective ablation of hippocampal CRH neurons increases seizure susceptibility.

Fig 8

a, Representative traces of EEG activity from control (AAV-GFP) and CRH neuron-ablated (AAV-DTA) mice demonstrating the induction of epileptiform and seizure activity by 10 mg/kg KA. b, Ablation of hippocampal CRH neurons significantly increased the total duration of KA-induced epileptiform activity compared to control mice (p<0.001 by unpaired Student’s t-test). c, Representative EEG traces from control (GFP+CNO) and CRH neuron-silenced (Gi+CNO) mice demonstrating KA-induced epileptiform and seizure activity. d, Silencing hippocampal CRH neurons had no impact on the total duration of epileptiform activity compared to control mice (p = 0.75).