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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Nat Struct Mol Biol. 2017 Jul 3;24(8):643–651. doi: 10.1038/nsmb.3427

Figure 3.

Figure 3

Interactions of FI SP domain with FH CCP2-3 and C3b CUB. (a) FH CCP2 and CCP3 and FI SP are shown with interacting residues shown in sticks. (b) FI SP domain binds first scissile loop in C3b CUB domain in its active site. Shown are the scissile loop with cleavage site at R1303 and S1304 of C3b CUB, with R1303 bound to D519 of FI SP; the catalytic center of FI SP with D429, H380 and A525 (serine in wild-type FI) and I340 of the N-terminal tail of SP stabilizing the oxyanion hole. Color scheme as defined in Figure 1.