Expression of proteins associated with trophic support was assessed after 24 (A) and 48 (B) hours of binge exposure, Binge alcohol caused a decrease in pCREB, BDNF and trkB at 24 hours in females, whereas males showed a decrease in pCREB only. Binged males showed an increase in IGFR at 24 hours, but binged females did not show this until 48 hours, at which point IGF-1 was downregulated in binged animals of both sexes. At 48 hours, binged males had normalized expression of pCREB, but binged females did not. *p < 0.05 significantly different from same sex control.